SPOILER
The mace of disruption is in the bath of blood on the top floor of the Vampire base. It is on the left through a secret door as you enter the main chamber of the lair with Haz's golem. You take damage when you get it I believe. There are a couple of Vamps in the room but nothing too unpleasant.
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TUOR, Excrutiatingly Jolly Aerie executioner of the HADB and all round not so nice guy.
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