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You can do these quests later as well, although when you change the chaper without completing them, the Journal will be cleared of these and you just need to remember yourself, as to what you have to do. That's why you either do them all in C2, or try to get as little as possible of them in C2, get the cash, and save them for lateron.
I personally do not suggest to "skip" these - after all, these let you get some nice gear, cash, and most importantly - XP, which means levels. Which means stronger chars. And you WILL want stronger chars.
As for Asylum - that's the one way ticket. And why on earth would anyone want to skip Shark City?
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