1) There are certain areas that damp out spells...this was mentioned in the manual and probably included to prevent people just popping out of dungeons at the first sign of trouble.
2) There are certain areas that damp out specific spells...ever tried firestorm in the water?
3) There are certain conditions, such as being boogred, which increase the odds of spell failure...I was running 1 for 3 in the Boogre Caves, which can be lethal when trying to blow Lily Plants away/heal up or just a PITA when casting things like Spirit Eye.
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