Lower the better. Using this as an example, your saving throw versus spells is 8. This means that you need to roll an 8 or higher to avoid being affected by a particular spell. (Determined by a virtual 20 sided die). If you need to save at a negative number:
take silence 15' radius - you need to save at -5 therefore you would need a 13 or higher to avoid being silenced.
Hope this helps.
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