My keys... happened last year. I was flying out on a trip, and was using a new carry-on bag (yet another conference bag). I tossed the keys into a back section (I think), which turned out to be a false pocket -- a place you could slide the handle of your roller bag through so that the computer bag would stay nicely attached on top of it.
Haven't seen 'em since... man, did that stink, 'cause there were remote key fobs for both our cars on there.