Well, I got pretty badly beaten first time I took on the twisted rune. Second time I pulled my party right back into the first room and picked them off one at a time; for the lich you can just summon cannon fodder to absorb the timestop/symbols, then holy smite, continual breach and regular attacks, same as any other lich. The beholder I lured into the room with a fireball, then beat up with myself, Jaheira and Korgan, all hasted. The vampire I beat alone with the help of chaotic commands and neg. plane protection, and I let the mage get killed by her own pit fiend. : )
Oh, and that unarmed assassin... well, he's not even worth mentioning.
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