The stone heads in that area all give clues about how to defeat the enemies in each of the four rooms. IIRC, fire is the only thing that will kill it (I'm almost positive that's it, although I can't confirm it at the moment). So use Wand of Heavens, Flame Blade, Fire Wand, Burning Hands, Agannazar's Scorcher, Flame Arrow, Fireball, etc.
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