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Not being able to wear boots or helmet just reduces your options for armor and enchanting. I have never worn a helmet and it has not affected my character. As for shoes I would probably slightly miss them especially since I made a pair with permanent levitation.
As for skills not to take. I concur with Acrobatics and Athletics. You can use these constantly so they are not needed as major or minor skills unless you want to level up quickly.
I would recommend at most two weapon skills. Just remember if you have a low strength you will not be able to carry much.
Also unless you have a decent strength I would avoid the armor skills. A full suit of armor weighs alot even for light armor.
Also as a note you only will get spells for schools that you select as Major. With higher ability you will get more spells for that particular school.
Hope these suggestions help.
Have fun!!!!
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