I've desexed 7 of my lil' partners, the males tend to be curious as to where their "partners" went, they were only groggy for about two days after the operation.
Don't feed them too much *they hurl up the food straight away otherwise* just give them some comfort and company and they'll get over it!
As for picking them up, I cradled them in my arms so as not to put pressure on any one part of their bodies.
Otherwise listen to the far more insightful and helpful Lady Sedai's post!