No issues here really. If you have any emulation software in use such as Daemon it will insist that these be removed before the game starts (which is a pain if you use a virtual third drive), but otherwise it doesn't cause problems. The game itself takes awhile to start up, which I think is the copy protection check that is taking up most of the time.
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Still I feel like a child when I look at the moon, maybe I grew up a little too soon...
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