It depends on some things, if you have Yoshimo in your party you have a free spot anyway (which is why I think it's crucial to have Yoshimo when going to Spellhold- also because of the traitor-storyline which is nice I think). If you haven't done the De'Arnise stronghold quest yet, you can ditch Nalia and then you can always pick her up again when going to the De'Arnise Stronghold. I think storyline-wise you should definitely keep Imoen, but with regard to stats and abilities you're right that she's not the best NPC in the game, so it might not hurt to lose her. Still, I think in highter levels she's quite a decent mage. Her mage skills are even better than Jan's because he isn't an allround mage but an illusionist, but of course Imoen could never even come near him with reagrd to thieving skills
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