This is something I'm curious about too, though i never got a lot of interaction anyway other than Jahiera complainging and Yoshimo drilling everyone for info. In fact all of the npcs had more interaction with each other. But to answer your question, no the editors shouldn't affect things like character interactions. Maybe you did something that offended them. I turned my characters off when I slept with a drow prostitute and Phaere in the underdark as this was against my lawful good alignment. Following your alignment affects characters relationships a great deal
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