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To make a potion you have to have two different ingredients that have a commom effect. To make a simple potion of fatigue take a piece of bread and a small Karma Egg.
There is a Alchemy Recipe book in Pedgalia(??, sorry not at home to get the spelling correct) upstairs in the General Store that tells how to make other potions. I also found the book in Ebonheart.
I have just been making fatigue potions to raise the alchemy skill, since the higher the alchemy skill level the more effects you will know about the ingredients.
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