Try Compatibility Mode, right click on the Deep6.exe program while in Windows Explorer.
It might be a sound problem, try setting all sound to 0.
Edit:
On the files page of John Hubbard's site there are two W&W save games available for download. Load one of these saves and then try moving things in the Shrine of Anephas. This may clarify whether it is your save games that are at fault, or not.
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