Run through your stuff. See if you've completed the quest relating to it. If you've done the Umar Hills / Temple of Amaunator quest and still have the morn ritual, you can safely drop it. If you've killed the illithid underneath the temple district and are still holding onto the sewer key, get rid of it. I've found there's no need to be a packrat at all in this game; I've only regretted dropping something once (the light gem to get into Adalon's lair - d'oh). Fill your bag of holding with heavy objects and items with smaller numbers next to them (for instance, don't put 120 frost arrows in there) and you won't have any problems. Items are still counted as 'in your possession' if they're in the bag of holding.
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