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I noticed that ray of enfeeblement quirk too. Basically non-party characters don't have an "encumbrance check" so even if their STR goes down to 3 and they're carrying a two-handed sword and full plate armour, they won't be encumbered and immobilised. However the spell will affect their STR-based THAC0 and damage bonus. I think that characters get a significant penalty to hit and damage if they have a very low STR. This makes the spell quite good against giants, trolls, umberhulks and similar creatures with a very high strength, since it drastically reduces the damage they do to you.
As for vampires seeing invisible characters - a number of enemy types, including vampires, demons, and, strangely, kuo-toa - can see straight through invisibility or stealth, even if you have Non-Detection. The only way to safely scout the area when they're around is to use a Wizard Eye.
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