Simon
Are you sure you went into the correct buidling? IIRC (and I'm sure I do as I only recently completed the Bridge District portion of the plot). The house with the lich in the basement in pretty near the SW corner of the map, next to the house with the "man in red" quest. OTOH, the route to the tanner's house is pretty circuitous - I remember having to go down to the waters' edge then back up a flight of stairs right up to the top level.
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"Butt-kicking for goodness!" - Minsc
"Cities always teem with evil and decay. Let's give it a good shake and SEE WHAT FALLS OUT!!" - Minsc