For anything that regenerates, you have to find a way to increase your damage per round. I don't know what class your playing, but hasting yourself always works. Also, summoning in extra helpers for more damage potential helps; Kitthix and Horn of Valhalla are useable by any class. If you can slow or hold a regenerating creature, you also slow or stop their regeneration. Try using Kitthix's Ensnare ability, or the Flail of Ages for slow effect.
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"Many are my names in many countries. Mithrandir among the Elves, Tharkun to the Dwarves; Olorin I was in my youth in the West that is forgotten, in the South Incanus, in the North Gandalf; to the East I go not"
--The Two Towers
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