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Not likely with a motherboard swap. I have seen instances where Windows XP has survived a mobo swap... but most of the time you need to reinstall the OS when you change something that major.
Upgrade graphics card - ok
More Memory - ok
Faster Processor - ok as long as your old mobo supports the new speed
Sound, mouse, Keyboard - ok
Motherboard - NOT OK
as a general rule you'll want to uninstall the drivers that support your old card BEFORE replacing it with the new one.
Things to worry about with mobo swap:
Power Supply (new mobo/processor combo's require large power supplies, 300 Watts should be considered the absolute minimum imo, and don't by the cheapo generic brand... get a good one... Antec, Fortron, etc...)
Case - especially with Athlons (HOT), you'll want to make sure your case has adequate cooling... most older cases should be replaced. OR you could go liquid cooled like I did on my fastest system (no more cooling problems)
Memory - most older memory... if it will work at all, will slow your new box down significantly. General rule... upgrading mobo?... upgrade Processor and Memory also.
Once you look that over you'll realize that if you're considering a mobo upgrade... you're best bet is to probably buy a new system (especially if you're a computer noob), which is my recommendation to most people these days.
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