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Not including the storyline NPCs in your party will severly effect quest generation, romances, and the plot. Several of the storyline NPCs "develop" as the story progresses. . . Not having the intial "crew" will make it impossible to finish the story. You should have at the very least: Jahiera, Imoen, Yoshimo to make it to the end. Almost every NPC you allow to join your party will eventually generate a specific quest.
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