If you don't want the caracters you'll meet you can do it. If it's your first time however I think you should use a party,so you can get the basics and use startegies. The first game a party is best , not ony for the basics but the NPC interactions are very cool. If you solo your first game there isn't a new challenge.
For the mods I think you should play the game first the way the developers meant the game to be played. The game is great and mods are just for a new experience.
Having an one alignment (or as less as possible) party is handy cause NPCs won't leave for the reputation if you keep it as low/high as it should be for your alignment. The NPC interactions between different allignments are cool though. You'll always have different alignments since there aren't that many NPCs.
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