I send each of my tanks to take out one demon, my weaker spell casters together to take out a third demon, and my thief and semi strong fighter to take out the last demon. After that, I heal, then attack Irenicus, keeping my spell casters back to wear him down. When the person he's concentrating on gets hurt badly, I pull them out, let him attack some one else, heal them, then send them back in. I never let my main character get too badly hurt, so I don't kill them and have to start over.
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