to be sincere, im not sure if it affects saving throws in general, id say that it doesnt, but some spells descriptions say things like "the victim has to do a saving throw according to his wisdom..." (not exact words, ive tried to translate it from spanish), so i think that some spells (spells that affect the mind, like xrayted82 said)
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"Sigh" -Ertai, Captive of the Blinding Angel