Most of the areas in the Graveyard District for Korgan and Edwin's quests can be accessed without them...it's just that the scroll won't be there. The treasure (and beaucoup traps!) will be there though.
-Sazerac
P.S. It does go without saying that you have to have the NPC in your party to trigger their particular quest, like Nalia's abduction, or Keldorn's domestic difficulties, or Cernd's kid. Other NPC's have quests that are actually stronghold quests that you can do without them, like Aerie and the Planar Prison (bard stronghold), or Minsc and the Umar Hills (Ranger stronghold).
"S"
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"And all my days are trances, and all my nightly dreams,
Are where thy grey eye glances, and where thy footstep gleams,
In what ethereal dances, by what eternal streams..."
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