Playing with your main character as the only player generated character and the rest NPCs is going to be best for the first time through. The NPC interactions are very entertaining. They are indeed a huge part of the game. Later on you can try making custom parties. With your own player generated party you do lack the NPC interactions but it is also great fun to play with classes or combinations of classes that are not simply available among the NPCs. You can try playing with a party entirely consisting of mages, for example. Fun stuf like that.
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