Ditto Diablo II, though not really for space reasons; when I realize I'm playing too much, I freak & uninstall the thing... then come back & reinstall it a couple months later.
Oh, and the original Thief and Thief II, though not so much uninstalls. Whenever I get a new computer/laptop/PoS, the first thing I do is pull out the Thief CDs and install it... it's kind of a ritual chicken sacrifice for the future good luck of the machine