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I didn't encounter that problem, and I was just at that point a day or two ago. I used the collar to dominate a flayer (if you've killed them all, one always seems to regenerate in the room with the blood). Then I select him and one other party member and point them to the door together. I make sure they are both in the vicinity of the door, then click on the door, and it opens. I don't think you can just have the flayer selected though to open the door. Make sure you have a party member selected as well. Hope it works.
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