Here's my thoughts:
Skills:
*Block - I'm not sure I agree with Block being based on Endurance but perhaps they needed Endurance raising skills (assuming the level-up system is similiar to that of Morrowind.
*Blunt/Blade - I don't like that they've merged the combat skills. I don't like it at all. A player who have used a dagger for most of the game will find that he's also a master swordsman.
You can master all melee weapans with only two skills.
*Athletics - An Endurance skill, not a Speed skill. Nuff' said.
*No spears and staves - I'm one of those guys that wanted one-handed spears. Well, we don't get it, not even spears at all. And they've took away the staves for good measure as well. I must have been praying to the wrong Daedra lately.
The rest looks fine.
Magic:
Nothing to comment on other than the fact that Mysticism doesn't fit as an Intelligence based skill.
Stealth:
Acrobatics shouldn't be based on Speed, otherwise all good. I wait with anticipation to see the new stealth system.
Birthsigns:
*The Lady - Nerfed but still OK. I don't know why they exchanged the Personality bonus for a Willpower bonus, though.
*The Lover - Seriously nerfed. Why did they take away the Agility Bonus? I mean, It's not like the Lover was a overpowered sign or anything. A 10 points permanent bonus to Personality would fit great here.
*The Serpent - This much-maligned sign has gotten a much-needed powerboost. Curing yourself and dispelling spells on yourself while using the special ability sounds like an interresting idea. Let's just hope it doesn't dispel your own protective magic you've gotten up.
The rest looks OK; the Thief looks like a very interresting choice.