[Radek]

Uninstalling a plugin during a game can result in problems, especially, if the saved game depends on the plugin (plugin-specific items in the inventory or in your chests, and so on). It can, that means, it need not.
At any rate, save the game before you start adding or removing plugins. In the worst case, you'll be always able to return to your saved game (after restoring the original situation as far as the plugins are concerned) if problems occur.