Loading and saving you're stuck with, uninstalling mods is the only way to speed that up. Other than the usual defrag if you haven't done that in a few months.
The Abu Manor would probably fit your bill, it's in Ald-Ruhn so handy for the mages guild and silt strider.
http://unforgottenrealms.net/downloa...n=file&id=1132
Personally I prefer Abu's retreat which is much more homely and has a nice display room in there. And it's only a two minute levitate from Seyda Neen and the silt strider.
http://unforgottenrealms.net/downloa...n=file&id=1191
If you're a wizard, I've just stumbled across this extemely well done Telvanni tower in Tel Branora. It has direct access to all major guilds and a few other places and has a nice little quest with it as well. And some mannequins which you'll find downstairs in a box to place as you will. The site is designed by a monkey so I can't give you a URL, just go to
http://www.rpgplanet.com/morrowind/modcontrols/mods.asp and click the big search button, then in the top right field, but "serene" next to title and press go. It should be the only result.
As for your frame rate, the best boost will come from turning off real time shadows by sliding the slider fully to the left. That'll really help. The frame rate optimiser here
http://morrowind.nm.ru/Morrowind%20FPS%20Optimizer/ might also help, although that'll increase frame rate at the expense of viewing distance so it might not be your cup of tea.
Hope some of that helps.