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1. No you can never get rid of the drain luck side effect but yes if you add two other ingredients that restores luck you can offset it. However I think you can only get the potion that fortifies and restores strength if you use three ingredients so you can't do it with that potion as you don't have two slots left.
2. yes your alchemy skill as well as your intelligence and apparati effect the power and potency of your potions. The higher they are the longer you potions will last and the more powerful they will be.
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