Being a girl who doesn't hit people of either gender, I can't really comment on girls hitting guys and vica versa and all that. It's a rather silly thread anyways, desu ne? Put in a brawl, I wouldn't stop to consider gender.
In an in-game sense, it's said many times that gender has very little to do with the game beyond appearance/romance... so a female tank is just as... ah... tankish as any man. So then doesn't it boil down to that other thread,
wizard vs. fighter, with a few rogues and clerics thrown in? Most everyone agreed that the wizard could beat the warrior hands down. By that reasoning, the only way guys could win was with their superior numbers! But Aerie, Nalia, and Imoen all tossing off Horrid Wilting narrows down the field a bit... and
Edwin (the only male wizard to my knowledge) is a turncoat anyways, right?
So maybe this isn't such a clear-cut victory for the guys, now is it?
Their only hope, really, is Jan....