heya!
have you gotten your drivers updated for your mouse? this game requires that you use the most recent drivers for everything else, so may as well get good mouse drivers too.
com port shouldn't make a difference. but if you have another kind, say USB, lying around, give it a try. sometimes the problem is just the device itself!!
yes, desktop and game rez should be all exactly the same.
did you by any chance use your in-game options for adjusting your mouse? give it a go. ya never know.
let us know. meantime i will do some more research for you.
V***V
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