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David,
This should really be an easy battle.
My tactic is to summon the 3 toughest monsters available to my NPC's and (I usually have both Imoen and Nalia) have my mages create Simulacrums. Drink any necessary potions and cast any required protection magics on your party. Place your monsters near where Irenicus's monsters spawn in. Place your mage's clones away from there Iren's monsters spawn, but close enough to cast spells on the bad guys.
NOW once you're completely ready ... THEN perform the little ritual with the tears of Bhaal that spawns in Irenicus.
Have your toughest fighter attack the slayer/Irenicus. Have your monsters and remaining fighters wipe out the enemy monsters. Have your mages cast breeching spells on Irenicus as needed and attack spells on the enemy monsters otherwise. Having one of your mages cast a horrid Wilting spell centered in Irenicus will really help take the starch out of the enemy monsters.
Good Luck!
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