How did you get in to the asylum, If you pretended you were crazy and got admitted then you cannot open the door to the portal(the key is in Irenicus's quarters near the entrance of the asylum, and the door leading there is locked.
If you used the wardstone then you enter though the entrance so the door isn't locked and you can get the key to the portal(when you are leaving the asylum that is) well I hope that makes sense.
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