I usually try to get a majority of the side quests done before going after Imoen...the thing is, there a few side quests that are extremely difficult to complete if you haven't gained a certain level of power. the best example of this would be the Twisted Rune. However, as far as the regular side quests go, it i's a good idea to take care of these before sailing out to Spellhold. This gives you a good chance to finish up sub-quests for the NPCs in your party as well, and build up a badass party for Spellhold/Underwater City/the Underdark (since this is a huge chunk of XP and what not, I am very selective about who is in my party at this point in the game.)
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