The first party I took into ToB consisted of myself (kensai/mage), keldorn, viconia, minsc, sarevok, and edwin. No thief. And it wasn't too hard. Knock and detect traps help. And sometimes (i'm at a loss why it doesn't always work) you can trip a trap with a summoned creature, which is cool. Other times I'd just send keldorn in with his 65% magic res and high hp and hope for the best. So its definately possible, but with my assasin in my new party its much more fun.
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