Well, Baldur's gate 2 TOB will put in 2 major areas to the Baldur'gate world. One area appears on your worldmap, it can be accessed during the regular game. The other part is a add-on, which I believe can only be accessed after you go to Hell and beat the Slayer.
SO I believe the one part you can access during a regular game, and the 2nd part you'll have to go to the end of Baldur's gate and beat your foe in Hell, and that will start the add-on quest.
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