I've never gone solo (or actually finished BG2), but...
I get the impression that some aspects are easier - read the diary on Baldurdash web site for some good hints.
Things like - protection from magic/undead (protect your _entire_ party!), no more annoying AI (I'm going to walk over the trap to get there...). Definately easier to keep track of battles. I think the vital thing is choice of character - A multi mage/thief may well work well IMO, but there's been good discussion about this elsewhere.
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