Well your first problem is running... I always try to walk...walking around in cirlces keeps you less dizzy. Second... I recommend doing a few quests before the main story line kicks in. The equipment and exp yo uget is very valuable. Secondly, I usualy left one spot open to do the character quests so that they may come with me, give a few more hints and usually have a bit of extra skill for that particular area. Then after the main story line I stick with one gun (Valgyr for me) to beef up and romp around. But then it is just my take on things.
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