I tried to do all the outside of the city quests at once, then I went and did quest as quickly as possible in the city. Some people like to get all the little quests from ch 2&3 out of the way before doing the main line quests. Gets your party pretty high levels before you go down the main line quests. Some people from a role playing perspective, would get the main line done, then come back for all the side quests. I just did them as they came up and tried to not talk to anyone. Just do the ones you want to first, and try to prioritize. Do quests that are close together. AND HAVE FUN!
BK