Others have had similar problems. From my understainding it has to do with memory allocation and that the game does not free up the memory once it is no longer needed.
When it happens to me, I do the same -- quit and reboot.
In specific games I have found that the slowdown is related to certain spell effects like confusion and such and that resting brings everything back to speed, but this may just be a coincidence.
Also, when I helped install BG2 on a friend's machine, I noticed that leaving the processor speed at average worked better than configuring the processor speed as fast. You also might want to disable the game's 3-D effects and check the installation's readme.txt file for other suggestions regarding certain types of video and sound cards.
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