There must be about a zillion posts on killing Mindflayers on this board so I suggest you read em all (use the search button)
Most hints are along the lines of 'drink Intelligence potions'(they drain your intelligence, when you hit zero you're dead - works on dumbheads like Minsc), 'Lure the mindflayers out one by one' (with a thief hiding in shadows), 'Go Improved invisible, Cast wand of Cloudkill in room, run away and close the door behind you. Repeat until dead'
Just read the posts...they say it a lot better than I do.
good luck!!!
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