I started the game in multiplayer with three of my own characters and then transfered that file to a single player save game. That way you don't miss out on the healing spells cast upon rest thing.
I personally like how my party is set up now. Three slots for yourself gives you a good opportunity to experiment with other classes and the three npc slots gives you the room to do some of their quests.
You could always go 5 of your own and one npc. Just transfer out that npc to do their quests. Make sure you balance out those 5 slots though so it does not matter who the other npc is.
I am playing with Undead Hunter, (Half Orc) Wizard Slayer, and a Fighter that I dual classed to a theif right away ('cause I don't like Yoshimo nor Iomoen). The other npcs I usually have in my party are Nalia, Aerie, and Jaheira.
Between the undead hunter and the wizard slayer, I haven't had much trouble with anything in the game so far.
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