I don't like the wizard slayer at all. The berserker is a far better kit in my opinion (actually, it's the only fighter kit I'm fond of). It's just not worth that extra pittance of magic resistance to not be able to use things like the ring of gaxx and the cloak of cheating. I specialise in two-handed swords; there are a lot of good two-handed swords in the game. If I was going to start another character and specialise in something else, I'd go with katanas and shieldfighting; the celestial fury +3 is priceless. I've found magical longswords to be abundant, but unfortunately relatively mediocre.
Of course, perhaps you want to specialise in ranged weapons; in that case go with long bows or short bows, there aren't many good crossbows in the game (in fact there aren't many crossbows in the game, period).
In any case, good luck.
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