It's simple. Attack and kill all the demons first. Throw everything you can at them. leave Irenicus for the moment. He spends all his time bringing up his own protective spells anyway. Once you kill all the demons Irenicus teleports to the other side of the room. He can't see you and you can't see him because of the fog of war. Now is your chance to heal yourselves, replenish defensive spells etc. Now wait. Irenicus' protective spells will soon wear off. Then attack him when he's defenceless. Piece of cake. Keep hitting him with missile weapons to disrupt his spell casting.
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