When you start the game you lose everything anyway so the only way around it is to start a multiplayer game THEN import your character(s)
Every class (nearly) has a diffrent stronghold, each one is obtained through a quest, and every quest is diffrent, if you want spoilers ask and you shall reccive all the data.
The only quests that are lost are the ones you only get when you have a specific NPC in your party. The rest are all inculded
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