Personally I have not tried a good / evil combination, but one of the problems I could forsee would be that if your reputation drops to far i.e. 1 or 2 then good aligned characters would leave the party, while evil NPC's would love it, and vice versa for a high reputation with evil NPC's.
I suppose that the only way to play this would be to make sure your reputation stays neutral(ish), but then you would always miss out on the cheap prices in the stores and temples.
Cheers....Mine's a beer
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