I'm only trying the game for the first time with all my own characters now but i'm sure you can finish it alright this way. You do miss out on quests though as the different npcs have several special quests during the game as their past comes back to haunt them. I found you also don't get all the quests if you pick up characters late in the game for instance. You also don't get any interaction between the characters, romances etc at least as far as I've seen, and i'm up to chapter three. Of couse you wouldn't get them complaining about your actions either!
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