Actually, the Master Brain is a pushover. It is the minions that gives you 'trouble'.
I usually have a level 12+ Mage by that point in the game, assuming that I am playing a party. I simply cast one, yes, one Chromatic Orb and the silly Master Brain dies.
Skeleton Warriors and Blunt Weapons handle the Mind Flayers, Umber Hulks and the Brain Golems.
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